Dupilumab, a human monoclonal antibody against interleukin- 4 receptor alpha, inhibits signaling of interleukin- 4 and interleukin- 13, type 2 cytokines that may be important drivers of atopic or allergic diseases such as atopic dermatitis. Eli Lilly announced positive results from a Phase 3 trial which investigated galcanezumab in the treatment of episodic cluster headaches. Nov 15, · Dupilumab is a monoclonal antibody that inhibits IL- 4 and IL- 13 signaling by blocking the shared IL- 4Ra.
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The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Dupilumab phase 2 clinical trial in diabetes. In two randomized, placebo- controlled, phase 3 trials of. Nov 15, · Atopic dermatitis ( AD) is a pruritic disease of unknown origin that usually starts in early infancy ( an adult- onset variant is recognized) ; it is characterized by pruritus, eczematous lesions, xerosis ( dry skin), and lichenification ( thickening of the skin and an increase in skin markings).
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It is indicated for adults with moderate- to- severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.